Same issue with a '21 Calligraphy; presets for both mine and my wife's profiles will randomly disappear. I feel like we started to experience this problem shortly after completing the November update late last year but I can't remember for certain. If that's the case, I'd imagine we're stuck dealing with it until the new April update is released. However, if anyone has found a solution, I'd definitely give it a go and see if it fixes our issue.